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Mohamed Bentires-Alj, Pharm, Ph.D.
Friedrich Miescher Institute for Biomedical Research (FMI)
Maulbeerstrasse 66
CH-4058 Basel / Switzerland |
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Mohamed Bentires-Alj is a junior group leader at the Friedrich Miescher Institute for Biomedical Research in Basel. His group is interested in normal mammary gland development and breast cancer. His lab focuses on signaling pathways that underlay mammary gland differentiation and breast cancer/metastasis. To achieve these goals, they use three dimensional cultures, FACS sorting of mammary stem cells and breast tumor initiating cells, mouse cleared fat pad transplantation assay and transgenic and knockout mice.
Bentires-Alj group has numerous national and international collaborations and is a part of the European network of breast development and cancer (www.enbdc.org).
For additional information, see http://www.fmi.ch/bentires-alj.m/
Selected original publications
- Bentires-Alj M, Paez JG, David FS, et al. (2004). Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia. Cancer Res. 64:8816-8820.
- Bentires-Alj M, Gil SG, Chan R, Wang ZC, Wang Y, Imanaka N, Harris LN, Richardson A, Neel BG. and Gu H. (2006). A role for the scaffolding adapter GAB2 in breast cancer. Nature Medicine 12:114-121.
- Bentires-Alj M, Kontaridis M. and Neel BG. (2006). Stops along the RAS pathway in human genetic disease. Nature Medicine 12:283-285.
- Bentires-Alj M. and Neel BG. (2007). Protein-tyrosine phosphatase 1B (PTP1B) is required for HER2/Neu-induced breast cancer. Cancer Res. 67:2420-2424.
- Stewart RA, Sanda T, Widlund HR, Zhu S, Swanson KD, Hurley AD, Bentires-Alj M, Fisher DE, Kontaridis MI, Look AT. and Neel BG. (2010). Phosphatase-dependent and -independent functions of Shp2 in neural crest cells underlie LEOPARD syndrome pathogenesis. Developmental Cell 18:750-762.
Reviews
- Bentires-Alj M, Clarke RB, Jonkers J, Smalley M. and Stein T. (2009). It's all in the details: methods in breast development and cancer. Breast Cancer Res. 11:305.
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