Stem Cell Center of Competence ::: Uni Basel, Switzerland
 

 
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Dr. Joerg Betschinger

 
 

Dr. Joerg Betschinger
Friedrich Miescher Institute for Biomedical Research (FMI)
Maulbeerstrasse 66
CH-4058 Basel/Switzerland

 
E-mail joerg.betschinger@fmi.ch
Phone +41 61 69 78556
Fax +41 61 69 73976
 
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Joerg Betschinger is a Group Leader at the Friedrich Miescher Institute for Biomedical Research in Basel.

Cell identity is encoded in self-propagating regulatory networks that confer cell state stability. Most cells, however, acquire their identity during development by transiting through progressively restricted cell states. Thus, destabilization of existing and emergence of prospective regulatory networks underlies cell fate determination, and is reflected in the lineage progression from stem and progenitor cells into mature cell types.

Our research aims at deciphering mechanisms and logics driving cell state transitions using pluripotent stem cells as a paradigm. In particular, by combining genetic and biochemical approaches, we target the identification of modules that regulate cell state changeover, to specify the underlying network dynamics, and to deduce routines conferring network plasticity.

 

Selected original publications related to stem cells

  • Betschinger J, Nichols J, Dietmann S, Corrin PS, Paddison PJ, Smith A. (2013). Exit from Pluripotency is Gated by Intracellular Redistribution of the bHLH Transcription Factor Tfe3. Cell 153:335-47.

  • Betschinger J, Mechtler K, Knoblich JA. (2006). Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells.Cell 124:1241-53.