Tewis Bouwmeester is Senior Unit Head in the Department of Developmental and Molecular Pathways (DMP) at the Novartis Institutes for Biomedical Research (NIBR) in Basel. He is a trained developmental biologist working in the field of regenerative medicine. His group is part of a regenerative medicine initiative to identify low molecular weight compounds and/or secreted factors that can activate adult tissue stem/progenitor cells such as intestinal crypt cells and hematopoietic precursors to regenerate damaged and/or aged tissues. In addition, he has an interest in dissecting the mechanisms of lineage restriction by identifying compounds (stem cell differentiators) that can drive embryonic stem cells into a defined somatic lineage. His group has core expertise in “state of the art” quantitative proteomics technologies to: i) dissect regulatory protein-protein interactions in vivo, ii) identify and quantify post translational modifications such as phosphorylation and iii) to monitor global proteome changes in response to growth factors and/or upon lineage commitment.
For additional details, see http://www.nibr.com
Original publications
- Bouwmeester T,* Bauch A, Ruffner H, et al. (2004). A physical and functional map of the human TNFa/NF-kB signal transduction pathway. Nature Cell Biol. 6:97-105.
*corresponding author.
- Gavin A-C, Aloy P, Grandi P, Krause R, et al. (2006). Proteome survey reveals modularity of the yeast cellular machinery. Nature 30:631-636.
- Bantscheff M, Eberhard D, Abraham Z, et al. (2007). A quantitative chemical proteomics approach reveals novel modes of action of clinical Abl kinase inhibitors. Nature Biotech. 25:1035-1044.
- Huang SM. et al. (2009). Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature 461:614-620.
|