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Dr. Tewis Bouwmeester

 
 

Dr. Tewis Bouwmeester
Developmental Molecular Pathways (DMP)
Novartis Institutes for Biomedical Research (NIBR)
Novartis Pharma AG
Forum 1, Novartis Campus
CH-4056 Basel / Switzerland

 
E-mail tewis.bouwmeester
@novartis.com
Phone +41 61 324 41 29
Fax +41 61 324 76 55
 
Homepage
 
 

Tewis Bouwmeester is Senior Unit Head in the Department of Developmental and Molecular Pathways (DMP) at the Novartis Institutes for Biomedical Research (NIBR) in Basel. He is a trained developmental biologist working in the field of regenerative medicine. His group is part of a regenerative medicine initiative to identify low molecular weight compounds and/or secreted factors that can activate adult tissue stem/progenitor cells such as intestinal crypt cells and hematopoietic precursors to regenerate damaged and/or aged tissues. In addition, he has an interest in dissecting the mechanisms of lineage restriction by identifying compounds (stem cell differentiators) that can drive embryonic stem cells into a defined somatic lineage. His group has core expertise in “state of the art” quantitative proteomics technologies to: i) dissect regulatory protein-protein interactions in vivo, ii) identify and quantify post translational modifications such as phosphorylation and iii) to monitor global proteome changes in response to growth factors and/or upon lineage commitment.

For additional details, see http://www.nibr.com

Original publications

  • Jagani Z, Mora-Blanco EL, Sansam CG, McKenna ES, Wilson B, Chen D, Klekota J, Tamayo P, Nguyen PT, Tolstorukov M, Park PJ, Cho YJ, Hsiao K, Buonamici S, Pomeroy SL, Mesirov JP, Ruffner H, Bouwmeester T, Luchansky SJ, Murtie J, Kelleher JF, Warmuth M, Sellers WR, Roberts CW. and Dorsch M. (2010). Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway. Nature Medicine 16:1429-33.
     
  • Bonavia A, Franti M, Pusateri Keaney E, Kuhen K, Seepersaud M, Radetich B, Shao J, Honda A, Dewhurst J, Balabanis K, Monroe J, Wolff K, Osborne C, Lanieri L, Hoffmaster K, Amin J, Markovits J, Broome M, Skuba E, Cornella-Taracido I, Joberty G, Bouwmeester T, Hamann L, Tallarico JA, Tommasi R, Compton T. and Bushell SM. (2011). Identification of broad-spectrum antiviral compounds and assessment of the druggability of their target for efficacy against respiratory syncytial virus (RSV). Proc Natl Acad Sci USA 108:6739-44.
     
  • Schmitges FW, Prusty AB, Faty M, Stützer A, Lingaraju GM, Aiwazian J, Sack R, Hess D, Li L, Zhou S, Bunker RD, Wirth U, Bouwmeester T, Bauer A, Ly-Hartig N, Zhao K, Chan H, Gu J, Gut H, Fischle W, Müller J. and Thomä NH. (2011). Histone methylation by PRC2 is inhibited by active chromatin marks. Mol Cell 42:330-41.
     
  • Hao HX, Xie Y, Zhang Y, Charlat O, Oster E, Avello M, Lei H, Mickanin C, Liu D, Ruffner H, Mao X, Ma Q, Zamponi R, Bouwmeester T, Finan PM, Kirschner MW, Porter JA, Serluca FC. and Cong F. (2012). ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. Nature 485:195-200.
     
  • Bassilana F, Carlson A, DaSilva JA, Grosshans B, Vidal S, Beck V, Wilmeringwetter B, Llamas LA, Showalter TB, Rigollier P, Bourret A, Ramamurthy A, Wu X, Harbinski F, Plonsky S, Lee L, Ruffner H, Grandi P, Schirle M, Jenkins J, Sailer AW, Bouwmeester T, Porter JA, Myer V, Finan PM, Tallarico JA, Kelleher JF 3rd, Seuwen K, Jain RK, Luchansky SJ. (2014). Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39. Nat Chem Biol. 10:343-9.
     
  • Pecho-Vrieseling E, Rieker C, Fuchs S, Bleckmann D, Esposito MS, Botta P, Goldstein C, Bernhard M, Galimberti I, Müller M, Lüthi A, Arber S, Bouwmeester T, van der Putten H, Di Giorgio FP. (2014). Transneuronal propagation of mutant huntingtin contributes to non-cell autonomous pathology in neurons. Nat Neurosci. 17:1064-72.
     
  • Krumova P, Reyniers L, Meyer M, Lobbestael E, Stauffer D, Gerrits B, Muller L, Hoving S, Kaupmann K, Voshol J, Fabbro D, Bauer A, Rovelli G, Taymans JM, Bouwmeester T, Baekelandt V. (2015). Chemical genetic approach identifies microtubule affinity-regulating kinase 1 as a leucine-rich repeat kinase 2 substrate. FASEB J. 29:2980-92.
     
  • Stein C, Bardet AF, Roma G, Bergling S, Clay I, Ruchti A, Agarinis C, Schmelzle T, Bouwmeester T, Schübeler D, Bauer A. (2015). YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers. PLoS Genet. 11:e1005465.
     
  • Bidinosti M, Botta P, Krüttner S, Proenca CC, Stoehr N, Bernhard M, Fruh I, Mueller M, Bonenfant D, Voshol H, Carbone W, Neal SJ, McTighe SM, Roma G, Dolmetsch RE, Porter JA, Caroni P, Bouwmeester T, Lüthi A, Galimberti I. (2016). CLK2 inhibition ameliorates autistic features associated with SHANK3 deficiency. Science 351:1199-203.
     
  • Planas-Paz L, Orsini V, Boulter L, Calabrese D, Pikiolek M, Nigsch F, Xie Y, Roma G, Donovan A, Marti P, Beckmann N, Dill MT, Carbone W, Bergling S, Isken A, Mueller M, Kinzel B, Yang Y, Mao X, Nicholson TB, Zamponi R, Capodieci P, Valdez R, Rivera D, Loew A, Ukomadu C, Terracciano LM, Bouwmeester T, Cong F, Heim MH, Forbes SJ, Ruffner H, Tchorz JS. (2016). The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size. Nat Cell Biol. 18:467-79.