Ravi Jagasia is a laboratory head at F. Hoffmann-La Roche, Basel, CNS Research focusing on adult neurogenesis and neural stem cell biology.
During, his postdoc he focused on models of CNS neuroregeneration (maturation of newborn granule neurons in the adult dentate gyrus) and neurodegeneration of the nervous system ( in vivo model for astrocyte induced mitochondrial dysfunction). In rodent models, the majority of adult born neurons die, but increased hippocampal activity can promote incorporation into the dentate gyrus. The major focus of research is the cell intrinsic activity dependent mechanisms regulating the survival and integration of newborn neurons. Ravi Jagasia continues to maintain strong scientific relationship with his former postdoc supervisors lab, Chichung Lie at the Helmholtz Center in Munich.
Adult neurogenesis contributes to learning and memory, and defects are linked to depression in humans. The goal of the current research has a strong focus on translational neuroscience, attempting to identify novel strategies to induce endogenous adult neurogenesis using neural stem cell cultures, rodent models and imaging strategies. The lab is involved in collaborations Roche has developed with iSTEM (Evry, France), and Ludwig Aigner (PMU Salzburg, Austria).
For additional details, see http://www.roche.com/
Selected original publications related to stem cells
- Jagasia R, Grote P, Westermann B. and Conradt B. (2005). DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans. Nature 433:754-760.
- Jagasia R, Steib K, Englberger E, Herold S, Saxe M, Gage FH, Song.H and Lie DC. (2009). GABA-CREB signalling regulates maturation and survival of newly generated neurons in the adult hippocampus.J Neurosci. 24:7966-77.
Reviews
- Jagasia R, Song H, Gage FH. and Lie DC. (2006). New regulators in adult neurogenesis and their potential role for repair. Trends in Molecular Medicine 12:400-5.
- Chapouton P, Jagasia R. and Bally-Cuif L. (2007). Adult neurogenesis in non-mammalian vertebrates. Bioessays, 29: p. 745-57.
- Jagasia R* and Lie DC*. (2009). Hippocampal neurogenic niche and regulation of adult neurogenesis”. Chapter in book “Postnatal and adult neurogenesis,” Research Signpost.
- Costa M, Jagasia R. and Berninger B. (2009) Assessing and directing the neuronal differentiation of embryonic and adult derived neurosphere cells.Chapter in book “Protocols for Neural Cell Culture”Humana Press.
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