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Home > Research > Topics > Daniel F. Kalbermatten


 

Prof. Dr. Dr. Daniel F. Kalbermatten

 
 

Prof. Dr. Dr. Daniel F. Kalbermatten
MD, MPhil, PhD, FMH, EBOPRAS
Department of Plastic, Reconstructive and Aesthetic Surgery, Handsurgery
University Basel     
Spitalstrasse 21
4031 Basel / Switzerland

 
E-mail Daniel.Kalbermatten@usb.ch
Phone +41 61 265 73 49
Fax +41 61 265 73 01


Group:
Dr. Mathias Tremp
Dr. Moritz Meyer v.S.
Dr. Elizabeth A. Kappos
Dr. Patricia Engels


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Daniel Kalbermatten is a Head Investigator at the Department of Plastic, Reconstructive and Aesthetic Surgery and Hand Surgery. His group mainly focuses on different aspects of regenerative cells and repair, the effects of growth factors on nerve regeneration and neuropathies and their clinical treatment.

Recent studies indicate that adipose tissue contain nascent stem cells. Those adipose-derived stem cells (ADSC) can differentiate along classical mesenchymal lineages resulting in the formation of fat, bone and cartilage tissue as well as neuronal cells. Previous experiments have shown that it is possible to induce ADSC to adopt a stem cell phenotype which, when transplanted into nerve conduits, enhance peripheral nerve regeneration.  Also, our group has shown that fibrin scaffolds represent an excellent method for transplantation of cells and has developed a new full fibrin conduit to bridge gaps in nerve lesions. Recent experiments have shown that fibrin supports the growth and differentiation of mesenchymal stem cells (MSC). Under aseptic conditions, nerve conduits will be constructed from a fibrin glue to cross a 1 cm nerve gap. In order to deliver effectively any cells at the injury site they must be suspended in a suitable 3D matrix within the fibrin conduit construct. Our studies showed a superior nerve regeneration distance in the fibrin conduit (A) compared with PHB (B) material (see Image).
Our ultimate goal is to use a bioengineered cellular scaffolds in a humaninjury model to determine the potential for undifferentiated adipose derived stem cells to enhance regeneration of tissues. The idea of using a physiological fibrin clot and beneficial cells in a tunnelled shape combined with the easy application and the familiarity of the surgical community with fibrin glue might create a new treatment option for gaps that has no significant donor morbidity. The different projects, spanning both basic science and clinical problems, integrate the work of scientists and plastic surgeons.
The group has a tight link with The Blond McIndoe Laboratory in Manchester (Prof. Terenghi) as well as with the University of Umea in Sweden (Prof. Wiberg).


Recent publications

  • Erba P, Mantovani C, Kalbermatten DF, Pierer G, Terenghi G, Kingham PJ. (2010). Regeneration potential and survival of transplanted undifferentiated adipose tissue-derived stem cells in peripheral nerve conduits. J Plast Reconstr Aesthet Surg. 63:e811-7.
     
  • Di Summa PG, Kalbermatten DF, Pralong E, Raffoul W, Kingham PJ, Terenghi G. (2011). Long-term in vivo regeneration of peripheral nerves through bioengineered nerve grafts. Neuroscience 181:278-91.
     
  • Kalbermatten DF, Schaadxs D, Kingham PJ, Wiberg M. (2011). Neurotrophic activity of human adipose stem cells isolated from deep and superficial layers of abdominal fat. Cell Tissue Res. 344:251-60.
     
  • Wettstein R, Erba P, Itin P, Schaefer DJ, Kalbermatten DF. (2013). Treatment of basal cell carcinoma with surgical excision and perilesional interferon-α. J Plast Reconstr Aesthet Surg. 66:912-6.
     
  • Wettstein R, Savic M, Pierer G, Scheufler O, Haug M, Halter J, Gratwohl A, Baumberger M, Schaefer DJ, Kalbermatten DF. (2014). Progenitor cell therapy for sacral pressure sore: a pilot study with a novel human chronic wound model. Stem Cell Res Ther. 5:18.
     
  • di Summa PG, Kingham PJ, Campisi CC, Raffoul W, Kalbermatten DF. (2014). Collagen (NeuraGen®) nerve conduits and stem cells for peripheral nerve gap repair. Neurosci Lett. 572:26-31.
     
  • Tremp M, Meyer Zu Schwabedissen M, Kappos EA, Engels PE, Fischmann A, Scherberich A, Schaefer DJ, Kalbermatten DF. (2015). The regeneration potential after human and autologous stem cell transplantation in a rat sciatic nerve injury model can be monitored by MRI. Cell Transplant. 24:203-11.
     
  • Kappos EA, Engels PE, Tremp M, Meyer Zu Schwabedissen M, di Summa P, Fischmann A, von Felten S, Scherberich A, Schaefer DJ, Kalbermatten DF. (2015). Peripheral Nerve Repair: Multimodal Comparison of the Long-Term Regenerative Potential of Adipose Tissue-Derived Cells in a Biodegradable Conduit. Stem Cells Dev. 24:2127-41.
     
  • Tremp M, Menzi N, Tchang L, di Summa PG, Schaefer DJ, Kalbermatten DF. (2016). Adipose-Derived Stromal Cells from Lipomas: Isolation, Characterisation and Review of the Literature. Pathobiology 83:258-66.


( Tremp, Kalbermatten, Meyer z.S., Kappos )