Stem Cell Center of Competence ::: Uni Basel, Switzerland
 
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Prof. Claudia Lengerke

 

 
 

Prof. Claudia Lengerke
Departement of Biomedicine
University Hospital Basel
Hebelstr. 20
CH-4031 Basel / Switzerland

 
E-mail claudia.lengerke@unibas.ch
Phone +41 61 55 65 129
Fax ++41 61 265 44 50
 
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Claudia Lengerke is research Group Leader at the Department of Biomedicine and attending physician at the University Hospital Basel. The research group “Stem Cells and Hematopoiesis” aims to understand the molecular mechanisms driving blood stem cell formation during development and the role of reactivated embryonic stem cell pathways in cancer biology. Cancer stem cells, reported in leukemia as well as several types of solid tumors, are thought to be responsible for tumor induction, maintenance, metastasis as well as relapse after conventional therapies. Elucidating the cellular hierarchies in tumors and the molecular mechanisms underlying cancer stem cell identity are therefore major research goals.
We use the zebrafish model and in vitro differentiating human induced pluripotent stem cells for our developmental studies and perform xenotransplantation of human tumor cells into zebrafish or mice to study human tumorigenicity in vivo. Transplantion of single human tumor cells into transgenic zebrafish lines is especially suited for understanding tumor heterogeneity, cancer stem cell identity and for the analysis of the crosstalk between cancer (stem) cells and their niche.
Our group has moved in 2013 from Tübingen, Germany, to Basel and has close collaborations with several research groups abroad and increasingly also on-site.


Selected original publications

  • McKinney-Freeman S, Cahan P, Li H, Lacadie SA, Huang HT, Curran M, Loewer S, Naveiras O, Kathrein KL, Konantz M, Langdon EM, Lengerke C, Zon LI, Collins JJ, and Daley GQ. (2012). The transcriptional landscape of hematopoietic stem cell ontogeny. Cell Stem Cell 11:701-14.
     
  • Bareiss PM, Paczulla A, Wang H, Schairer R, Wiehr S, Kohlhofer U, Rothfuss OC, Fischer A, Perner S, Staebler A, Wallwiener D, Fend F, Fehm T, Pichler B, Kanz L, Quintanilla-Martinez L, Schulze-Osthoff K, Essmann F and Lengerke C. (2013). SOX2 expression associates with stem cell state in human ovarian carcinoma. Cancer Res. 73:5544-55.
     
  • Konantz M, André MC, Ebinger M, Grauer M, Wang H, Grzywna S, Rothfuss OC, Lehle S, Kustikova OS, Salih HR, Handgretinger R, Fend F, Baum C, Kanz L, Quintanilla-Martinez L, Schulze-Osthoff K, Essmann F and Lengerke C. (2013). EVI-1 modulates leukemogenic potential and apoptosis sensitivity in human acute lymphoblastic leukemia. Leukemia. 27:56-65.
     
  • Schaefer T, Wang H, Mir P, Konantz M, Pereboom TC, Paczulla AM, Merz B, Fehm T, Perner S, Rothfuss OC, Kanz L, Schulze-Osthoff K, Lengerke C. (2015). Molecular and functional interactions between AKT and SOX2 in breast carcinoma. Oncotarget 6:43540-56.
     
  • Lenard A, Alghisi E, Daff H, Donzelli M, McGinnis C, Lengerke C. (2016). Using zebrafish to model erythroid lineage toxicity and regeneration. Haematologica 101:e164-7.
     
  • Ecsedi M, Schmohl J, Zeiser R, Drexler B, Halter J, Medinger M, Duyster J, Kanz L, Passweg J, Finke J, Bethge W, Lengerke C. (2016). Anti-thymocyte globulin-induced hyperbilirubinemia in patients with myelofibrosis undergoing allogeneic hematopoietic cell transplantation. Ann Hematol. 95:1627-36.
     
  • Konantz M, Alghisi E, Müller JS, Lenard A, Esain V, Carroll KJ, Kanz L, North TE, Lengerke C. (2016). Evi1 regulates Notch activation to induce zebrafish hematopoietic stem cell emergence. EMBO J. 35:2315-2331.
     
  • Wang H, Schaefer T, Konantz M, Braun M, Varga Z, Paczulla AM, Reich S, Jacob F, Perner S, Moch H, Fehm TN, Kanz L, Schulze-Osthoff K, Lengerke C. 2017). Prominent Oncogenic Roles of EVI1 in Breast Carcinoma. Cancer Res. 77:2148-2160.
     
  • Paczulla AM, Dirnhofer S, Konantz M, Medinger M, Salih HR, Rothfelder K, Tsakiris DA, Passweg JR, Lundberg P, Lengerke C. (2017). Long-term observation reveals high-frequency engraftment of human acute myeloid leukemia in immunodeficient mice. Haematologica 102:854-864.

 
Selected reviews

  • Lengerke C and Daley GQ. Autologous blood cell therapies from pluripotent stem cells. (2010). Blood Rev 24:27-37.
     
  • Konantz M, Balci TB, Hartwig UF, Dellaire G, André MC, Berman JN and Lengerke C. (2012). Zebrafish xenografts as a tool for in vivo studies on human cancer. Ann N Y Acad Sci. 1266:124-37.
     
  • Lengerke C, Fernandez-Capetillo O, Tolic-Norrelykke I, Barna M, Coleman T, Zamboni D. (2014). When the going gets tough: scientists' personal challenges. Cell 159:225-6.
     
  • Kanz D, Konantz M, Alghisi E, North TE, Lengerke C. (2016). Endothelial-to-hematopoietic transition: Notch-ing vessels into blood. Ann N Y Acad Sci. 1370:97-108.