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Ivan Martin is Professor of Tissue Engineering at the Institute for Surgical Research and Hospital Management, within the Department of Biomedicine and the Department of Surgery of the University Hospital Basel. His group combines interdisciplinary expertise in cell biology, biomedical engineering and materials science towards the generation of human cell-based three-dimensional (3D) tissues. The engineered constructs are being developed (i) as grafts for the treatment of traumas/diseases of the musculoskeletal system, and/or (ii) as 3D model systems to investigate fundamental aspects of cell differentiation and tissue development under controlled and defined conditions.
With reference to stem/progenitor cells, the group is generally interested in the role of soluble factors, physical forces and culture substrate material on maintenance of stem cell properties and induction of lineage-specific differentiation. The group has developed a bioreactor-based technique to expand bone marrow- or adipose tissue-derived stem cells within 3D porous polymeric or ceramic-based scaffolds, under direct perfusion flow. The system supports the possibility to expand and co-culture different progenitors (e.g., mesenchymal, endothelial, hematopoietic) in 3D environments, thereby achieving a superior maintenance of the multilineage cell differentiation capacity as compared to conventional culture in dishes or flasks. From a clinical standpoint, the vision of the group lies in the development of safe, standardized, scaleable and possibly cost-effective therapeutical processes based on the 3D culture of stem cells within specialized, closed, controlled and automated bioreactor systems.
The group has a tight link with the surgical disciplines of the University Hospital in Basel (e.g., plastic and reconstructive, orthopaedic) and is involved in different EC funded consortia (e.g., integrated project “STEPS” - http://www.stepsproject.com/). Ivan Martin is the European Chair of the Tissue Engineering and Regenerative Medicine International Society ( www.termis.org). He and his group have published more than 100 original papers. For additional details, see http://www.icfs-basel.ch/
Recent publications related to stem cells
- Braccini A, Wendt D, Jaquiery C, Jakob M, Heberer M, Kenins L, Wodnar-Filipowicz A, Quarto R. and Martin I. (2005). Three-dimensional perfusion culture of human bone marrow cells and generation of osteoinductive grafts. Stem Cells 23:1066-1072.
- Scherberich A, Galli R, Jaquiery C, Farhadi J. and Martin I. (2007). 3D perfusion culture of human adipose tissue-derived endothelial and osteoblastic progenitors generates osteogenic constructs with intrinsic vascularization capacity. Stem Cells 25:1823-1829.
- Scheufler O, Schaefer DJ, Jaquiery C, Braccini A, Wendt D, Gasser JA, Galli R, Pierer G, Heberer M. and Martin I. (2008). Spatial and temporal patterns of bone formation in ectopically prefabricated, autologous cell-based engineered bone flaps in rabbits. J Cell Mol Med. 12:1238-1249.
- Candrian C, Vonwil D, Barbero A, Bonacina E, Miot S, Farhadi J, Wirz D, Dickinson S, Hollander A, Jakob M, Li Z, Alini M, Heberer M. and Martin I. (2008). Engineered cartilage generated by nasal chondrocytes is responsive to physical forces resembling joint loading. Arthritis Rheum. 58:197-208.
- Müller AM, Davenport M, Verrier S, Droeser R, Alini M, Bocelli-Tyndall C, Schäfer DJ, Martin I. and Scherberich A. (2009). Platelet lysate as a serum substitute for 2D static and 3D perfusion culture of stromal vascular fraction cells from human adipose tissue. Tissue Eng. 15:869-875.
- Scotti C, Tonnarelli B, Papadimitropoulos A, Scherberich A, Schaeren S, Schauerte A, Lopez-Rios J, Zeller R, Barbero A. and Martin I. (2010). Recapitulation of endochondral bone formation using human adult mesenchymal stem cells as a paradigm for developmental engineering. PNAS 107:7251-7256.
- Martin I, Baldomero H, Tyndall A, Niederwieser D. and Gratwohl A. (2010). A Survey on Cellular and Engineered Tissue Therapies in Europe in 2008. Tissue Eng. Part A. Apr 7. In press.
Reviews related to stem cells
- Martin I, Miot S, Barbero A, Jakob M. and Wendt D. (2007). Osteochondral tissue engineering. J Biomech. 40:750-765.
- Martin I, Smith T. and Wendt D. (2009). A roadmap for the bioreactor-based translation of tissue engineering strategies into clinical products. Trends Biotech. 27:495-502.
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