Homeostatic neurogenesis in the adult hippocampus does not involve amplification of Ascl1high intermediate progenitors
Lugert S, Vogt M, Tchorz JS, Müller M, Giachino C. and Taylor V.
Publication in Nature Communications in February 2012, 3:670.
Drosha regulates neurogenesis by controlling Neurogenin 2 expression independent of microRNAs.
Knuckles P, Vogt MA, Lugert S, Milo M, Chong MM, Hautbergue GM, Wilson SA, Littman DR. and Taylor V.
Publication in Nature Neurosci. in June 2012, 15:962-969.
The group of Verdon Taylor at the Laboratory of Embryology and Stem Cell Biology
Department of Biomedicine Mattenstrasse demonstrated that Notch-dependent adult neural stem cells in the hippocampus generate differentiated neurons in a multistep process over several weeks. They identified a novel intermediate progenitor cell type and demonstrated the amplification of the lineage at the Tbr2(+) stage. In a second paper they demonstrated a novel function for the RNAse Drosha in the maintenance of neural stem cells that involves miRNA-independent destabilization of proneural mRNAs (including Neurog2).