| |
 |
| |
Dr. Antoine H.F.M. Peters
EMBO Young Investigator
Friedrich Miescher Institute for Biomedical Research (FMI)
Maulbeerstrasse 66
CH-4058 Basel/Switzerland
|
| |
|
| |
| Homepage |
| |
|
| |
|
 |
Antoine Peters is Group Leader at the Friedrich Miescher Institute for Biomedical Research in Basel. His group is interested in the epigenetic mechanisms that contribute to the heritability of cell identity of stem cells and during cellular differentiation and that safeguard genome stability. In particular, his group aims at understanding the role of and molecular interplay between histone methyltransferases, Polycomb group proteins and DNA methyltransferases in epigenetic (re)programming in mouse in-vitro systems as well as in pre-implantation and early post-implantation embryos. Towards these goals, his group performs gain- and loss-of-function studies in stem cells, in germ cells in which gene deficiency is induced at specific stages of their development, as well as in pre- and post-implantation embryos conditionally deficient for maternal and/or zygotic gene expression of epigenetic regulators. As functional readouts, the group analyzes the formation and function of heterochromatin, gene transcription, establishment and maintenance of genomic imprinting, nuclear organization, and cell fate.
The group has several collaborations with other groups in Basel and abroad. Antoine Peters is a selected member of the Network of Excellence The Epigenome (http://www.epigenome-noe.net) and is since 2008 an EMBO Young Investigator. He and his group have published more than 40 original publications.
For additional details, see http://www.fmi.ch/peters.a
Selected original publications related to stem cells
- Van der Heijden GW, Derijck AAHA, Posfai E, Ramos L, Gielen M, Pelczar P, Wansink DG, van der Vlag J, Peters AHFM. and de Boer P. (2007). Chromosome-wide nucleosome replacement and H3.3 incorporation during mammalian meiotic sex chromosome inactivation.Nature Genetics 39:251-258.
- Puschendorf M, Terranova R, Boutsma E, Mao X, Isono K, Brykczynska U, Kolb C, Otte AP, Koseki H, Orkin SO, van Lohuizen M. and Peters AHFM. (2008). PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos.Nature Genetics 40:411-420.
This manuscript was featured in: Packer A. (2008). Epigenetics: across the generations. Nature Rev. Gen. 9: 248-249.
- Terranova R, Yokobayashi S, Stadler MB, Otte AP, van Lohuizen M, Orkin SH. and Peters AHFM. (2008). Polycomb-group proteins Ezh2 and Rnf2 direct genomic contraction and imprinted repression in early mouse embryos.Developmental Cell 15:668-679.
This manuscript was featured in: Wu H-U. and Bernstein E. Partners in Imprinting: Noncoding RNA and Polycomb Group Proteins. Dev. Cell 15:637-638.
- Madan V, Madan B, Brykczynska U, Zilbermann F, Hogeveen K, Döhner K, Döhner H, Weber O, Blum C, Rodewald H-R, Sassone-Corsi P, Peters AHFM. and Fehling HJ. (2008). Impaired function of primitive hematopoietic cells in mice lacking the Mixed-Lineage-Leukemia homolog Mll5. Blood 113:1444-1454.
Reviews
- Hublitz P, Albert M. and Peters AHFM. (2009). Mechanisms of transcriptional repression by histone lysine methylation.International Journal of Developmental BioIogy. 53:335-354 (part of special issue on Epigenetics).
- Albert M. and Peters AHFM. (2009). Genetic and epigenetic control of early mouse development.Current Opinion in Genetics and Development 19:113-121.
|