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Home > Research > Topics > Primo L. Schär


 

Prof. Dr. Primo L. Schär

 
 

Prof. Dr. Primo L. Schär
Molecular Genetics
Department of Biomedicine, University of Basel
Mattenstrasse 28
CH-4058 Basel / Switzerland

 
E-mail

primo.schaer@unibas.ch

Phone +41 61 267 07 67
 
Homepage
 
 
 
Primo Schär is a Research Group Leader at the Department of Biomedicine of the University of Basel. His group investigates biological processes that modulate genome plasticity, i.e. the stability of the genetic and epigenetic codes of cell identity. The objective is to provide a thorough understanding of the molecular mechanisms involved and the consequences of their dysfunction for cell fate, transformation and cancer.

For additional information, see
https://biomedizin.unibas.ch/nc/about-us/people/profil/profile/person/pscha/


Recent publications related to stem cells:

  • Manser M, Sater MR, Schmid CD, Noreen F, Murbach M, Kuster N, Schuermann D, Schär P. (2017). ELF-MF exposure affects the robustness of epigenetic programming during granulopoiesis. Sci Rep. 7:43345.
     
  • Weber AR, Krawczyk C, Robertson AB, Kuśnierczyk A, Vågbø CB, Schuermann D, Klungland A, Schär P. (2016). Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism. Nat Commun.;7:10806.
     
  • Schuermann D, Scheidegger SP, Weber AR, Bjørås M, Leumann CJ, Schär P. (2016). 3CAPS - a structural AP-site analogue as a tool to investigate DNA base excision repair. Nucleic Acids Res. 44:2187-98.
     
  • Weber A., Schuermann D.* and Schär P.* (2014)  Versatile recombinant SUMOylation system for the production of SUMO-modified protein. PlosOne. in press. (*corresponding authors)
  • Cortazar D, Kunz C, Selfridge J, Lettieri T, Saito Y, MacDougall E, Wirz A, Schuermann D, Jacobs AL, Siegrist F, Steinacher R, Jiricny J, Bird A. and Schär P. (2011). Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability. Nature 470:419-423

  • Fritsch O, Burkhalter MD, Kais S, Sogo JM. and Schär P. (2010). DNA ligase 4 stabilizes the ribosomal DNA array upon fork collapse at the replication fork barrier. DNA Repair 9:879-888.

  • Focke F, Schuermann D, Kuster N. and Schär P. (2010). DNA Fragmentation in Human Fibroblasts Under Extremely Low Frequency Electromagnetic Field Exposure. Mutat. Res. 683:74-83.

Review:

  • Schuermann D, Weber AR, Schär P. (2016). Active DNA demethylation by DNA repair: Facts and uncertainties. DNA Repair (Amst). 44:92-102.
     
  • Jacobs A, and Schär P. (2011). DNA glycosylases: in DNA repair and beyond. Chromosoma 1-20.