| |
 |
| |
Dr. Dirk Schübeler
Friedrich Miescher Institute for Biomedical Research (FMI)
Maulbeerstrasse 66
CH-4058 Basel/Switzerland
|
| |
|
| |
| Homepage |
| |
 |
| |
|
 |
Dirk Schübeler is a Senior Group Leader at the Friedrich Miescher Institute for Biomedical Research in Basel. His group studies the role of epigenetic modifications of DNA and nucleosomes in transcriptional regulation and genome maintenance. A particular interest is the role of epigenetic regulation in stabilizing transcriptional programs in defined cellular states and how it relates to the developmental potential of a given cell. The regulation of pluripotency of stem cells and their epigenetic reprogramming during differentiation provide important models to address these questions. To understand how stem cell maintenance and loss of pluripotency are regulated via chromatin and DNA methylation the group develops and applies functional genomics approaches. With these quantitative measures of the epigenome are performed to identify regulatory patterns and their function in cell fate decisions.
Dirk Schübeler is an elected member of the European Network of Excellence “The epigenome”, an EMBO Young Investigator and member of the Swiss Systems Biology initiative on Cell Plasticity.
For additional details, see http://www.fmi.ch/schuebeler.d/
Original publications related to stem cells
- Weber M, Davies J, Wittig D, Oakeley E, Haase M, Lam WL. and Schübeler D. (2005). Chromosome-wide and promoter-specific analyses reveal sites of differential DNA methylation in normal and transformed human cells. Nature Genetics 37:853-62.
- Weber M, Hellmann I, Stadler M, Ramos L, Pääbo S, Rebhan M. and Schübeler D. (2007). Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome. Nature Genetics 39:457-466.
- Mohn F, Weber M, Rebhan M, Roloff TC, Richter J, Stadler MB, Bibel M. and Schübeler D. (2008). Lineage-specific Polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors, Molecular Cell 30:755-766.
- Hiratani I, Ryba T, Itoh M, Yokochi T, Schwaiger M, Chang C-W, Lyou Y, Townes TM, Schübeler D. and Gilbert DM. (2008). Global Re-organization of Replication Domains During Embryonic Stem Cell Differentiation. PLoS Biol. 6:2220-2236.
- Daujat S, Weiss T, Mohn F, Lange UC, Ziegler-Birling C, Zeissler U, Lappe M, Schübeler D, Torres-Padilla M-E. and Schneider R. (2009). H3K64 trimethylation marks heterochromatin and is dynamically remodeled during developmental reprogramming. Nature Struct Mol Biol. 16:777-782.
- Bell O, Schwaiger M, Oakeley EJ, Lienert F, Beisel C, Stadler MB. and Schübeler D. (2010). Accessibility of the Drosophila genome discriminates PcG repression H4K16 acetylation and replication timing. Nature Struct Mol Biol. 17:894-900.
Review articles related to stem cells
- Mohn F. and Schübeler F. (2009). Genetics and epigenetics: stability and plasticity during cellular differentiation. Trends in Genetics 25:129-136.
|