Stem Cell Center of Competence ::: Uni Basel, Switzerland
 

 
    Search    
 
  Research
     
 
   
 
 


 
 

 
   

back

   

Home > Research > Topics > Verdon Taylor


 

Prof. Verdon Taylor

 
 

Prof. Verdon Taylor
Embryology and Stem Cell Biology
Department of Biomedicine
University of Basel
Mattenstrasse 28
CH-4058 Basel/Switzerland

 
E-mail

verdon.taylor@unibas.ch

Phone +41 61 695 30 91
Fax +41 61 695 30 90
 
Homepage
 
 
 
 
Verdon Taylor is Professor of Embryology and Stem Cell Biology in the Department of Biomedicine of the University of Basel. His group studies neural stem cell maintenance and differentiation. Using genetic approaches, he addresses the signaling mechanisms that regulate neurogenesis during development and in the adult mammalian brain. In particular, the group focuses on Notch signaling and its functions in controlling neural stem cell activity and fate, and novel downstream pathway components. Combining in vivo and in vitro gain- and loss-of-functions approaches with pathophysiological stimuli, he aims to understand how the local niche environment affects neurogenesis during disease and aging. Due to the poor capacity of the adult brain to regenerate neurons following disease, trauma or the effects of aging, he develops reporter systems to identify neural stem cells and monitor changes in their function and activity state during these events. In addition, he is interested in the role of endogenous stem and progenitors cells in brain tumor formation and in niche pathways that are potentially hijacked by tumor initiating cells. His group has generated models of brain tumors and uses conditional genetics to study how brain tumor-initiating cells are regulated, how they migrate and how they invade the brain. His group has several collaborations with groups in Basel and Internationally and he has published more than 50 original papers in the area of stem cells.

 
Recent publications related to stem cells:

  • Lugert S, Basak O, Knuckles P, Häussler U, Haas C, Fabel K, Goetz M, Kempermann G, Giachino C. and Taylor V. (2010). Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and aging. Cell Stem Cell 6:445-456.
     
  • Basak O, Giachino C, Fiorini E, MacDonald HR. and Taylor V. (2012). Neurogenic subventricular zone stem/progenitor cells are Notch1-dependent in their active but not quiescent state. J Neurosci. 32:5654-66
     
  • Lugert S, Vogt M, Tchorz JS, Müller M, Giachino C. and Taylor V. (2012). Homeostatic neurogenesis in the adult hippocampus does not involve amplification of Ascl1high intermediate progenitors. Nature Communications 3:670.
     
  • Knuckles P, Vogt MA, Lugert S, Milo M, Chong MM, Hautbergue GM, Wilson SA, Littman DR. and Taylor V. (2012). Drosha regulates neurogenesis by controlling Neurogenin 2 expression independent of microRNAs. Nature Neurosci. 15:962-969.
     
  • Giachino C, Basak O, Lugert S, Knuckles P, Obernier K, Fiorelli R, Frank S, Raineteau O, Alvarez-Buylla A, Taylor V. (2014). Molecular diversity subdivides the adult forebrain neural stem cell population. Stem Cells. 32:70-84.
     
  • Giachino C, Barz M, Tchorz JS, Tome M, Gassmann M, Bischofberger J, Bettler B, Taylor V. (2014). GABA suppresses neurogenesis in the adult hippocampus through GABAB receptors. Development 141:83-90.
     
  • Giachino C, Boulay JL, Ivanek R, Alvarado A, Tostado C, Lugert S, Tchorz J, Coban M, Mariani L, Bettler B, Lathia J, Frank S, Pfister S, Kool M, Taylor V. (2015). A Tumor Suppressor Function for Notch Signaling in Forebrain Tumor Subtypes. Cancer Cell 28:730-42.
     
  • Rolando C, Erni A, Grison A, Beattie R, Engler A, Gokhale PJ, Milo M, Wegleiter T, Jessberger S, Taylor V. (2016). Multipotency of Adult Hippocampal NSCs In Vivo Is Restricted by Drosha/NFIB. Cell Stem Cell 19:653-662.
     
  • Fedele S, Collo G, Behr K, Bischofberger J, Müller S, Kunath T, Christensen K, Gündner AL, Graf M, Jagasia R, Taylor V. (2017). Expansion of human midbrain floor plate progenitors from induced pluripotent stem cells increases dopaminergic neuron differentiation potential. Sci Rep. 7:6036.

Reviews

  • Taylor V. (2011). Hippocampal stem cell: so they are multipotent! J Mol Cell Biol. 3:270-272.
     
  • Lugert S. and Taylor V. (2011). Neural stem cells: disposable, end-state glia? Cell Stem Cell 8:464-465.
     
  • Giachino C, Taylor V. (2014). Notching up neural stem cell homogeneity in homeostasis and disease. Front Neurosci. 8:32.
     
  • Rolando C, Taylor V. (2014). Neural stem cell of the hippocampus: development, physiology regulation, and dysfunction in disease. Curr Top Dev Biol. 107:183-206.
     
  • Zhang R, Engler A, Taylor V. (2017). Notch: an interactive player in neurogenesis and disease. Cell Tissue Res. doi: 10.1007/s00441-017-2641-9. [Epub ahead of print]