Stem Cell Center of Competence ::: Uni Basel, Switzerland






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Prof. Dr. Fiona Doetsch

Prof. Dr. Fiona Doetsch
Biozentrum, University of Basel
Klingelbergstrasse 50/70,
CH-4056 Basel, Switzerland

Phone +41 61 267 22 30
Fax +41 61 267 21 48

Fiona Doetsch is a Research Group Leader at the Biozentrum of the University of Basel. Her research group investigates stem cells in the adult mammalian brain. The aim is to define the identity, lineages and regulation of adult neural stem cells. Elucidating the molecular and cellular pathways underlying their regulation may provide insight into brain repair.

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Recent publications related to stem cell research:

  • Paul A, Chaker Z, Doetsch F. (2017). Hypothalamic regulation of regionally distinct adult neural stem cells and neurogenesis. Science 356:1383-1386.
  • Silva-Vargas V, Maldonado-Soto AR, Mizrak D, Codega P, Doetsch F. (2016). Age-Dependent Niche Signals from the Choroid Plexus Regulate Adult Neural Stem Cells.
    Cell Stem Cell 19:643-652.
  • Crouch EE, Liu C, Silva-Vargas V, Doetsch F. (2015). Regional and stage-specific effects of prospectively purified vascular cells on the adult V-SVZ neural stem cell lineage. J Neurosci. 35:4528-39.
  • Silva-Vargas V. and Doetsch F. (2014). A new twist for neurotrophins: endothelial-derived NT-3 mediates adult neural stem cell quiescence. Neuron 83:507-9.
  • Codega P, Silva-Vargas V, Paul A, Maldonado-Soto AR, Deleo AM, Pastrana E. and Doetsch F. (2014). Prospective identification and purification of quiescent adult neural stem cells from their in vivo niche. Neuron 82:545-59.


  • Chaker Z, Codega P, Doetsch F. (2016). A mosaic world: puzzles revealed by adult neural stem cell heterogeneity. Wiley Interdiscip Rev Dev Biol. 5:640-658.
  • Silva-Vargas V, Crouch EE. and Doetsch F. (2013). Adult neural stem cells and their niche: a dynamic duo during homeostasis, regeneration, and aging. Current Opinion in Neurobiology 23:935-42.
  • Pastrana E, Silva-Vargas V. and Doetsch F. (2011). Eyes wide open: a critical review of sphere-formation as an assay for stem cells. Cell Stem Cell 8: 486-98.