Stem Cell Center of Competence ::: Uni Basel, Switzerland






Home > Research > Topics > A. Gratwohl


Prof. Dr. Alois Gratwohl


Prof. Dr. med. Alois Gratwohl
Former Head of Hematology
and former Head of Stem Cell Transplantation Team
Basel University Hospital
Petersgraben 4
CH-4058 Basel / Switzerland

Phone +41 61 361 16 00

Alois Gratwohl is retired Ordinary Professor for Hematology and Stem Cell Transplantation of the Medical Faculty, Head of Hematology and former director of the “Behandlungszentrum Stammzelltransplantation” at the University Hospital of Basel. He was instrumental in building up the reputation of hematopoietic stem cell transplantation (HSCT) in Basel. He is a pioneer in outcome research in HSCT with focus interests on graft-versus-host disease, risk assessment and activity. His seminal paper on the close link between chronic graft-versus-host disease and autoimmune diseases was published during his training at the National Institute of Health in Bethesda, USA. He established a simple risk score for outcome after allogeneic HSCT, which has become an instrument to assess risk for all allogeneic HSCT for haematological disorders in Europe. He coordinated or participated in multiple Swiss National Science Foundation (SNSF) research grants on HSCT since 1983; his last project dealt with risk assessment and factors associated with the use and outcome of HSCT. In collaboration with the Institute for Operations Research and Computational Finances of the University of St. Gallen, he defined the macro- and microeconomic factors associated with diffusion of modern medical technology, using HSCT as a model.

Alois Gratwohl co-founded the Basel Stem Cell Network, a Competence Centre of the University of Basel.

Recent publications related to stem cells

  • Gratwohl A. et al. (2009). Risk score for outcome after allogeneic hematopoietic stem cell transplantation: a Retrospective Analysis for the European Group for Blood and Marrow Transplantation and the European Leukemia Net. Cancer 115:4715-26.
  • Gratwohl A, Baldomero H, Schwendener A, Rocha V, Apperley J, Frauendorfer K. and Niederwieser D. (2009). The EBMT activity survey 2007 with focus on allogeneic HSCT for AML and novel cellular therapies. Joint Accreditation Committee of the International Society for Cellular Therapy; European Group for Blood and Marrow Transplantation. Bone Marrow Transplant. 43:275-91.
  • Gratwohl A, et al. (2010). Changes in the use of hematopoietic stem cell transplantation: a model for diffusion of medical technology. Haematologica 95:637-43.
  • Gratwohl A, et al. (2010). Worldwide Network of Blood and Marrow Transplantation. Hematopoietic stem cell transplantation: a global perspective. JAMA 303:1617-24.
  • Gratwohl A, Brand R, Niederwieser D, Baldomero H, Chabannon C, Cornelissen J, de Witte T, Ljungman P, McDonald F, McGrath E, Passweg J, Peters C, Rocha V, Slaper-Cortenbach I, Sureda A, Tichelli A. and Apperley J. (2011). Introduction of a quality management system and outcome after hematopoietic stem-cell transplantation. J Clin Oncol. 29:1980-6.
  • Urbano-Ispizua A, Baldomero H, Gratwohl A. (2012). Hematopoietic stem cell transplantation in Europe. Differences between Eastern and Western countries. Hematology 17 Suppl 1:S192-4.
  • Gratwohl A, Brand R, McGrath E, van Biezen A, Sureda A, Ljungman P, Baldomero H, Chabannon C, Apperley J. (2014). Use of the quality management system "JACIE" and outcome after hematopoietic stem cell transplantation. Haematologica 99:908-15.


  • Tyndall A. and Gratwohl A. (2009). Adult stem cell transplantation in autoimmune disease. Curr Opin Hematol. 16:285-91.
  • Gratwohl A. (2011). Cord blood meets its match. Lancet Oncol. 12:1177-8.
  • Gratwohl A. (2012). The EBMT risk score. Bone Marrow Transplant. 47:749-56.
  • Barbui T, Björkholm M, Gratwohl A. (2012). Optimizing investigator-led oncology research in Europe. Haematologica 97:800-4.
  • Gratwohl A, Niederwieser D. (2012). History of hematopoietic stem cell transplantation: evolution and perspectives. Curr Probl Dermatol. 43:81-90.
  • Gratwohl A, Baldomero H, Gratwohl M, Aljurf M, Bouzas LF, Horowitz M, Kodera Y, Lipton J, Iida M, Pasquini MC, Passweg J, Szer J, Madrigal A, Frauendorfer K, Niederwieser D; Worldwide Network of Blood and Marrow Transplantation (WBMT) (2013). Quantitative and qualitative differences in use and trends of hematopoietic stem cell transplantation: a Global Observational Study. Haematologica 98:1282-90.
  • Gratwohl A, Baldomero H, Passweg J. (2013). Hematopoietic stem cell transplantation activity in Europe. Curr Opin Hematol. 20:485-93.