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Dr. Christoph Patsch

Christoph Patsch, PhD
Stem Cell Platform
Roche Pharma Research and Early Development
Roche Innovation Center Basel
F. Hoffmann-La Roche Ltd
Grenzacherstrasse 124
CH-4070 Basel

Phone +41 61 688 21 04
Christoph Patsch heads a research lab within the Stem Cell Platform at Roche Innovation Center Basel. His group is engaged in internal drug discovery projects as well as external research collaborations leveraging iPS cell technology for translational in vitro models. His lab is actively involved in two European consortia – Innovative Medicines Initiative StemBANCC and – Horizon 2020 COSYN. Current main research activities are:

I) Modelling Alzheimer’s disease in patient iPS cell-derived 2D and 3D neuronal cultures to study the underlying pathological mechanisms.

II) Applying novel differentiation methods to generate vascular endothelial and smooth muscle cells to develop a model for endothelial dysfunction.

III) Assessing iPS cell-based in vitro models to bridge the gap between animal models and clinical trials.


For additional details, see

Recent publications related to stem cells

  • Patsch C*, Challet-Meylan L*, Thoma EC*, Urich E*, Heckel T, O'Sullivan JF, Grainger SJ, Kapp FG, Sun L, Christensen K, Xia Y, Florido MH, He W, Pan W, Prummer M, Warren CR, Jakob-Roetne R, Certa U, Jagasia R, Freskgård PO, Adatto I, Kling D, Huang P, Zon LI, Chaikof EL, Gerszten RE, Graf M, Iacone R, Cowan CA. (2015). Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells. Nat Cell Biol. 17:994-1003.
  • Dunkley T, Costa V, Friedlein A, Lugert S, Aigner S, Ebeling M, Miller MT, Patsch C, Piraino P, Cutler P, Jagasia R. (2015). Characterization of a human pluripotent stem cell-derived model of neuronal development using multiplexed targeted proteomics. Proteomics Clin Appl. 9:684-94.
  • Urich E*, Patsch C*,Aigner S, Graf M, Iacone R, Freskård PO. (2013). Multicellular self-assembled spheroidal model of the blood brain barrier. Sci Rep. 3:1500.
  • Patsch C, Kesseler D, Edenhofer F. (2011). Genetic engineering of mammalian cells by direct delivery of FLP recombinase protein. Methods 53:386-93.
  • Keramari M, Razavi J, Ingman KA, Patsch C, Edenhofer F, Ward CM, Kimber SJ. (2010). Sox2 is essential for formation of trophectoderm in the preimplantation embryo. PLoS One 5:e13952.
  • Patsch C*, Peitz M*, Otte D, Kesseler D, Jungverdorben J, Wunderlich FT, Brüstle O, Zimmer A, Edenhofer F. (2010). Engineering cell-permeant FLP recombinase for tightly controlled inducible and reversible overexpression in embryonic stem cells. Stem Cells 28:894-902.